MyBioSource.com's Anti-PBX1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence. The Anti-PBX1 Antibody, Rabbit Polyclonal was generated using PBX homeobox 1, and PBX1 as the antigen and it reacts with Human.
Description
PBX1 was abnormally overexpressed and its intracellular localization was found to be frequently amplified in many types of cancer, including renal clear cell carcinoma. PBX1 displays oncogenic activity in several different types of cells. PBX1 is a TALE homeodomain protein involved in the development of different types of cancers. Indeed, PBX1 is required for hematopoiesis as well as for multiple developmental processes such as skeletal patterning and organogenesis. PBX1 is a biological candidate gene for type 2 diabetes at the 1q21-q24 susceptibility locus